Subtype-specific multivariate analysis of factors associated with Cap+RT or 5FU+RT subjects demonstrated strong associations of immune, radiosensitivity, and stromal signatures with complete responders in specific CMS subtypes (A). Interaction-specific univariate regression analysis of signatures associated with complete response (CR) in specific CMS subtypes demonstrated cytotoxic lymphocytes as an important predictor of CR in this treatment cohort (B and C).
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Mahmood et al. (2024) studied this question.
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