Development of multiple human papillomavirus-16-associated digital squamous cell carcinomas and human papillomavirus-16-associated oral squamous cell carcinoma in an immunocompetent adult

The oncogenic role of human papillomavirus (HPV) in anogenital and oropharyngeal squamous cell carcinoma (SCC) is well-established.1 Skin and adnexal HPV-associated SCC primarily localizes to the hands and feet, particularly surrounding the nail bed.2 Approximately 60% to 80% of nail SCCs are associated with high-risk HPV subtypes, most commonly HPV-16.1 HPV-16 is also the subtype most often associated with oral SCC.2