Development and Validation of Spectrophotometric Methods for Determining Some Proton Pump Inhibitors

The study is devoted to the development and validation of methods for the spectrophotometric analysis of omeprazole and esomeprazole in the substance and various drugs. 96% ethyl alcohol was chosen as the general solvent. The operating wavelengths are 295 nm. The relative error of determination is ± 1.2% for “Omeprazole” capsules, ± 0.51% for “Omegast” capsules, ± 0.39% for “Esom” capsules, ± 0.32%. Validation of methods for the quantitative determination of omeprazole and esomeprazole in standard samples was carried out taking into account parameters such as specificity, linearity and accuracy.