Case report of a patient taking Baclofen regularly. When he developed kidney failure, Baclofen toxicity, as manifested by a gradual onset of delirium, developed. Only after dialysis was started, and improvement of his delirium occurred following dialysis led to a search of possible dialyzable medicines and Baclofin was found in his home medicines he regularly took. Baclofen neurotoxicity in dialysis patients is regularly recognized, but this seems to be the first report of a patient chronically on Baclofen developing neurotoxicity when renal failure developed.
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Yehudis et al. (2024) studied this question.
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