Comparison of Sedative and Hemodynamic Effects of Propofol Against Midazolam-Ketamine Combination in Children Undergoing Magnetic Resonance Imaging.

Introduction- The need for magnetic resonance imaging (MRI) in children is increasing for accurate diagnosis. Sedation is required in the pediatric population as they cannot remain stationary for a sufcient length of time, needed for the completion of the procedure. In this prospective single-bli Methods- nded randomized study, 100 children aged 1 month to 16 years who belong to the American Society of Anesthesiologist (ASA) status 1 and 2 admitted for MRI on a daycare basis were distributed into two groups. Group A(n=50) was sedated with Midazolam – Ketamine while group B (n=50) with Propofol. The effectiveness of sedation, hemodynamics and complications during the procedure and recovery period were recorded. In our study, 80 patients were randomized into 2 groups (Group A and Results- Group B). Group A received midazolam and ketamine combination and group B received propofol. 2 patients were excluded from group B because of the failure of induction. The quality of MRI evaluated in the study by us using a three-point scale -namely no movement, minor movement, and major movement. 45% patients in group A and 22.5% patients in group B had no movement during the examination No patient had major movement necessitating another scan. In our study, all patients in group A were administered Midazolam at a dose of 0.15mg/kg. The mean induction dose of propofol administered to the patients of group B was signicantly higher than the dose of ketamine administered to group A (1.96 ± 0.41 mg/kg vs 1.69 ± 0.45 mg/kg; pvalue0.01) Midazolam-Ketamine was found to be better than single-dose Propofol in children undergoin Conclusions- g magnetic resonance imaging.