July 14, 2024Cellular and Molecular Life SciencesOpen Access

A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels

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Authors

VRVijay ReniguntaPhilipps University of Marburg NXNermina XhaferriPhilipps University of Marburg ISImran Gousebasha ShaikhPhilipps University of Marburg

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Laboratory investigation reveals functional interactions between silent KV subunits and KV7 channels in recombinant cells, indicating versatile cross-family modulation of potassium conductance.

Key Points

Electrically silent KV subunits functionally interact with KV7 potassium channels, modulating their activity, biophysical properties, and surface expression in cell membranes.
Using co-immunoprecipitation and proximity labelling, recombinant assays reveal spatial coexistence and subunit-specific heterotetramer formation across KV channel families.
Single-cell transcriptomic analyses identify native cell types with this interaction, indicating versatile biological tuning of potassium conductance across distinct tissues.

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Renigunta et al. (2024) studied this question.

synapsesocial.com/papers/68e60562b6db6435875994a6 https://doi.org/10.1007/s00018-024-05312-1

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Implication

Laboratory investigation reveals functional interactions between silent KV subunits and KV7 channels in recombinant cells, indicating versatile cross-family modulation of potassium conductance.

A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels

Discussion

Member takes

Implication

Key Points

Cite This Study

A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels

Discussion

Member takes

Implication

Key Points

Cite This Study

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