Streptococcus dysgalactiae subsp. equisimilis (SDSE) is a type of bacteria that can cause various diseases such as wound infections, erysipelas, cellulitis, life-threatening necrotizing fasciitis, and streptococcal toxic shock syndrome. It is capable of infecting both animals and humans. In this study, we present a detailed analysis of the genome of the SDSE strain SCDR1, which belongs to Lancefield group G, emm type (stG6), and (MLST) sequence type (ST44). This is the first time this particular strain has been found in Saudi Arabia and the Middle East. Additionally, we provide a comprehensive comparative genomics analysis of this emerging human pathogen, SDSE. CDR-SD1 was isolated from a diabetic foot ulcer patient at King Saud University Our study found that SDSE strains have varying characteristics in producing virulence factors for pathogenicity to humans, based on their genome sequence and close relationship with GAS. This sheds light on the proposed pathogenic mechanisms of SDSE and may lead to further molecular epidemiological research.
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Saeb et al. (2024) studied this question.
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