Formulation and Evaluation of Lamotrigine Spherules with Robust Gelation Technique

Many freshly created high-potential medications have low water solubility, which is a challenge in formulation development. The study aimed to improve the solubility of Lamotrigine, a weakly soluble medication classified as BCS class II, by solid dispersion techniques. Lamotrigine solid dispersion was created using the solvent evaporation method, and the formulation was assessed using stability tests, Fourier transform infrared spectroscopy (FTIR), and physical properties. Preformulation investigations yielded satisfactory results, therefore pellets were formed and evaluated. Solid dispersion had a different pharmacokinetic profile than pure medication, which could be attributable to Lamotrigine's faster dissolution rate from solid dispersion