Clinical study demonstrates clonal deletion of donor-specific T cells in kidney transplant recipients, indicating a viable mechanism for achieving tolerance without long-term immunosuppression.
Induction of donor-specific tolerance is a promising approach to achieve long-term graft patency in transplantation with little to no maintenance immunosuppression. Changes to the recipient's T cell receptor (TCR) repertoire are understood to play a pivotal role in the establishment of a robust state of tolerance in chimerism-based transplantation protocols.
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David et al. (2024) studied this question.
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