Chemical synthesis demonstrates efficient construction of fully substituted difluoromethylpyrazoles, highlighting high regioselectivity under mild conditions.
A concise and efficient method for the construction of fully substituted difluoromethylpyrazoles is achieved by a cyclization reaction between difluoroacetohydrazonoyl bromides and 2-acylacetonitrile or malononitrile. The method features advantages such as mild reaction conditions, broad substrate scope, good product yields, and high regioselectivity.
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Wang et al. (2024) studied this question.
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