Key points are not available for this paper at this time.
Advanced analogs of piperidine and smaller homologues of tropane─3-substituted 6-azabicyclo3.1.1heptanes─were synthesized on a large scale using readily available bulk reagents. The key step of the approach involved the double alkylation reaction of malonate with
Chernykh et al. (2024) studied this question.