Diffuse Normolipemic Plane Xanthoma: Remarkable Dermatological Findings Observed in a Series of Patients

Diffuse normolipemic plane xanthoma (DNPX), a rare form of non-Langerhans cell histiocytosis, presents with xanthomatous skin lesions that develop independent of the serum lipid levels.It is commonly associated with hematologic diseases, which are usually diagnosed during the follow-up period. 1 Data regarding DNPX is generally limited to single case reports, except for two case series which included 11 (part of a compilation of 63 cases with different diagnoses) and 8 study participants. 1,2Thus, in this case series of seven patients with DNPX, we aimed to evaluate the clinical and histopathological features of xanthomatous lesions, associated skin conditions, and accompanying hematologic diseases.We observed some novel clinical features of DNPX that have not been previously described.Furthermore, we screened the clinical photographs of approximately 70 articles from the PubMed database, focusing on the various clinical appearances of this rare disease.