Characterizations of the new type symmetrically ligands and their Ag(I)-NHC complexes, and their Antimicrobial activity measurements

Abstract A new N,N'-disubstitute benzimidazolium ligand and its Ag(I)-NHC complex have been synthesized", along with its symmetric N,N'-disubstitute benzimidazolium derivative of N-Heterocyclic carbene ligands. It was possible to make alkyl bromides or both by N-alkylating 5,6-methyl-1H-benzo[d]imidazole with fluor or non-fluor benzyl alkyl halides. In situ deprotonation of compounds with Ag₂O and a catalyzed reaction with KPF₆ were used to speed up the synthesis of the Ag(I)-NHC complex. The structural properties of all molecules were elucidated by NMR spectroscopy, PXRD, FTIR, elemental and ICP analysis. The structure of Ag(I)-NHC complexes was identified by analyzing powder PXRD diffraction pattern. According to the analysis, a PF₆⁻ anion and two NHC ligands are coordinated with an Ag⁺ ion in a linear geometry in each fluorinated benzyl complex. The antimicrobial activities of the compounds against Gram-positive, Gram-negative bacteria and fungi showed that the minimum inhibitory concentration value is 0.25 µg/mL. Ag + ions bound to ionic ligands increased the antimicrobial effects of these compounds.