Figure 4 from The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer

Model tumors also have oxygen-dependent microbial strain differences. A, CT26 colorectal cancer tumors grown in immune-deficient hosts have increased microbial burden with increased hypoxia. B, CT26 colorectal cancer tumors grown in immune-deficient or immune-competent hosts can be stratified into low and high hypoxia groups by the tumor Buffa score. C, Metatranscriptomic identification of microbial strains spontaneously colonizing individual tumors. D, Volcano plot of strains identified in (C) with tropism for tumor of either high or low hypoxia score. E, Bray–Curtis distances of gut samples from nude and BALB/c mice, showing comparisons within each group and with each other. F, Venn diagram of species shared between nude and BALB/c mouse gut microbiomes. G, Enumeration of the consistencies between the mouse and human data. We show microbes enriched in hypoxic or normoxic tumors in humans and the particular mouse strain noted in the table.