July 9, 2024Frontiers in PharmacologyOpen Access

Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway

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Authors

JQJie QuRegeneron (United States)HPHui PeiAffiliated Hospital of Taishan Medical University XLXin-Ze LiWenzhou Medical University

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Implication

In vivo and in vitro animal experiment shows biomimetic EGCG nanoparticles alleviate diquat-induced kidney toxicity, suggesting potential clinical utility.

Key Points

Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury, suppressing reactive oxygen species and apoptotic cell death.
Treatment with 20 mg/kg b.w./day reduced blood urea nitrogen and serum creatinine, lowering inflammatory markers more than free EGCG.
Assessment using HK-2 cells and mice exposed to diquat evaluated pathology alongside the NF-κB and NLRP3 inflammasome pathway markers.
Highlights a biomimetic delivery method for kidney protection; mouse and cell models require further preclinical and clinical validation.

Cite This Study

Qu et al. (2024) studied this question.

synapsesocial.com/papers/68e60e42b6db6435875a116c https://doi.org/10.3389/fphar.2024.1414918

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Implication

In vivo and in vitro animal experiment shows biomimetic EGCG nanoparticles alleviate diquat-induced kidney toxicity, suggesting potential clinical utility.

Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

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