Design Characteristics of a Neoteric, Superhydrophilic, Mechanically Robust Hydrogel Engineered To Limit Fouling in the Ocular Environment

Current challenges with ocular drug delivery and the chronic nature of many ocular ailments render the use of traditional ocular devices for additional drug delivery purposes very attractive. To achieve this feat, there is the need to develop biomaterials that are biocompatible, mechanically robust for ocular applications, highly transparent (depending on the targeted ocular device), and with ultralow protein adhesion potential (the primary step in processes that lead to fouling and potential device failure). Herein is reported the facile synthesis of a novel, highly transparent, mechanically robust, nontoxic, bulk functionalized hydrogel with characteristics suited to scalable fabrication of ocular implantable and nonimplantable devices. Synergistic superhydrophilicity between methacrylated poly(vinyl alcohol) (PVAGMA) and zwitterionic sulfobetaine methacrylate was exploited to obtain a superhydrophilic polymer conjugate through facile photoinitiated cross-linking polymerization. Proton nuclear magnetic resonance (