July 9, 2024Egyptian Journal of Basic and Applied SciencesOpen Access

Phenotypic and prevalence correlation with recurrent KRAS G12C, G13D, and G22E mutations in colorectal adenocarcinoma

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Recurrent mutations in KRAS exon 2 occur in most colorectal adenocarcinoma tumors, with G12C, G13D, and G22E variants driving persistent ras pathway activation.
KRAS exon 2 mutations appeared in 83% of patients compared to 17% wild type, showing significant enrichment among younger individuals and female cohorts.
Analysis using polymerase chain reaction and sequencing evaluated KRAS exon 2 alterations across 173 colorectal adenocarcinoma cases and pathological grades.
Supports further prognostic evaluation of recurrent KRAS exon 2 mutations, highlighting their potential role in colorectal adenocarcinoma risk stratification.

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Implication

Cohort study reveals frequent KRAS exon 2 mutations linked to demographic and pathological features in colorectal adenocarcinoma, suggesting prognostic utility.

Cite This Study

Sabah Bresam (2024) studied this question.

synapsesocial.com/papers/68e60e52b6db6435875a19be https://doi.org/10.1080/2314808x.2024.2375091

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Implication

Cohort study reveals frequent KRAS exon 2 mutations linked to demographic and pathological features in colorectal adenocarcinoma, suggesting prognostic utility.

Phenotypic and prevalence correlation with recurrent KRAS G12C, G13D, and G22E mutations in colorectal adenocarcinoma

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Discussion

Implication

Cite This Study

Phenotypic and prevalence correlation with recurrent KRAS G12C, G13D, and G22E mutations in colorectal adenocarcinoma

Key Points

Discussion

Implication

Cite This Study

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