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July 9, 2024Stem Cell ResearchOpen Access

Establishment of a transgene-free iPS cell line (SDCHi007-A) from a young patient bearing a ATP1A2 mutation and suffering from Epilepsy

Hongwei Zhang Tong Zhang Yaping Wang Jianguo Shi Yao Meng Qi Zhang Qingwei Guo Chunhong Duan

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Abstract

Epilepsy is a chronic neurological disease. Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient diagnosed as epilepsy caused by ATP1A2 gene mutation. Induced pluripotent stem cells (iPSCs) were developed using non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and C-MYC. The established iPSC line (SDCHi007-A) displayed pluripotent cell morphology, high expression levels of pluripotency markers, differentiation potential in vitro, normal karyotype, and remaining the original ATP1A2 gene mutation.

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e60e57b6db6435875a1b6b https://doi.org/10.1016/j.scr.2024.103490

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