A study on non-vibration-exposed organs correlated indices as diagnostic biomarkers of hand-arm vibration syndrome

Objective The aim of the study is to explore the feasibility of using nonvibration-exposed organ-related indices as vibration-induced white finger (VWF) diagnostic biomarkers. Methods Individuals were selected from a factory in China using the judgment sampling method. They were divided into control (con), non-VWF, and VWF groups according to the presence/absence of exposure to hand-transmitted vibration and VWF. Blood samples were collected for ELISA tests. Results Analysis of receiver operating characteristic curves was done on six indicators to assess their diagnostic sensitivity for VWF. Area under the receiver operating characteristic curve for insulin was 0.909 and was 0.923 for aspartate aminotransferase. Conclusions Insulin and aspartate aminotransferase could be used as indices for the diagnosis of hand-arm vibration syndrome.