Bacillus Paralicheniformis: A potential candidate for natural antibacterial agents from marine macro-algae associated bacteria.

Antibiotic resistance poses a major global health threat, necessitating new approaches to treat bacterial infections. We isolated bacteria from the brown macroalgae Sargassum swartzii collected along the Indian coast. Of 279 isolates, 47.6% showed antibacterial activity against Staphylococcus aureus and Vibrio parahaemolyticus when screened. Ten potent isolates underwent analysis of biosynthetic gene clusters and 16S rRNA sequencing. Isolate MP-99 carried polyketide synthase (pks) and non-ribosomal peptide synthetase (nrps) genes and exhibited antibacterial effects.