Granulomatous inflammatory skin conditions exhibit diverse clinical and histologic presentations. Reactive granulomatous dermatitis (RGD) is a comprehensive term that encompasses palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis (IGD), and interstitial granulomatous drug reaction. RGD is typically associated with underlying systemic conditions, including highly reactive immune states (autoimmune diseases and infections), malignancy (hematologic and solid organ), and medications.
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Figueroa-Ramos et al. (2024) studied this question.
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