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July 5, 2024Cell ResearchOpen Access

Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering

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Authors

PCPeng ChengCMCong MaoJTJin Tang

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Cite This Study

Cheng et al. (2024) studied this question.

synapsesocial.com/papers/68e613b1b6db6435875a62f6https://doi.org/10.1038/s41422-024-00989-2
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  1. 1Protein multi‐level structure feature‐integrated deep learning method for mutational effect prediction2024 · 2 citations
  2. 2Functional effects of mutations in proteins can be predicted and interpreted by guided selection of sequence covariation information2024 · 3 citations
  3. 3Rapid directed evolution guided by protein language models and epistatic interactions2026 · 23 citations
  4. 4ProStab: Prediction of protein stability change upon mutations by protein language and inverse folding models2025 · 3 citations
  5. 5MutPPI+: a multimodal framework for predicting mutation effects on protein–protein interactions via mutation-path-based data augmentation2026