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July 5, 2024Cannabis and Cannabinoid Research

Genetic Evidence of Endocannabinoid System on Perceived Stress and Restricted Food Intake: The Role of Variants rs324420 in FAAH Gene and rs1049353 in CNR1 Gene

Tania Yadira Martínez-Rodríguez Elia Herminia Valdés Miramontes José Francisco Muñóz-Valle Zyanya Reyes-Castillo

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Abstract

The endocannabinoid system (ECS) is active in brain regions involved in stress, food intake, and emotional regulation. The CB1 receptor and the fatty acid amide hydrolase (FAAH) enzyme regulate the ECS. Genetic variants in the

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Martínez-Rodríguez et al. (2024) studied this question.

synapsesocial.com/papers/68e613c2b6db6435875a69ec https://doi.org/10.1089/can.2024.0077

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic PotentialClinical Trial · 2026 · 1 citations
2Coordinated epigenetic dysregulation of CNR1 and FAAH genes drives endocannabinoid system dysfunction in anorexia nervosa2025 · 1 citations
3Endocannabinoid Signaling and Mood RegulationOriginal Research · 2026
4Characterization of cell-type specific knockout of different elements of the endocannabinoid system in cortical glutamatergic neurons in the context of stress-induced behavioral phenotype2025
5Characterization of cell-type specific knockout of different elements of the endocannabinoid system in cortical glutamatergic neurons in the context of stress-induced behavioral phenotype2025

The Role of Genetic Variations in the FAAH rs324420 Polymorphism and its Interaction with CRHR1 rs110402 and CNR1 rs2180619 in Anxiety and- Trauma Related Symptoms After Military Deployment2024
Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF ‐3845: A regional analysis of the contribution of endocannabinoid signaling machinery2023
The contribution of baseline circulating endocannabinoids to individual differences in human pain sensitivity: a quantitative sensory testing study2025
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