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April 26, 2026BiomedicinesOpen Access

The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic Potential

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This review reveals mechanisms of endocannabinoid dysregulation in neuropsychiatric disorders, suggesting potential therapeutic strategies.

This research explores the role of the endocannabinoid system in neuropsychiatric disorders and identifies mechanisms of dysregulation.
Review of ECS components and their implications in neuropsychiatric disorders.
Assessment of therapeutic strategies targeting FAAH inhibition and plant-derived cannabinoids.
Discussion of genetic and epigenetic influences on ECS function.
Dysregulation of the ECS is linked to various neuropsychiatric disorders, impacting emotional and stress responses.
Therapeutic targeting of the ECS shows potential in restoring homeostasis without adverse effects.
Research highlights the need for personalized interventions due to variability in treatment responses.

Mušić et al. (2026) studied this question.

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This review reveals mechanisms of endocannabinoid dysregulation in neuropsychiatric disorders, suggesting potential therapeutic strategies.