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July 5, 2024

Figure S8 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

Takuma Uo Kayode K. Ojo Cynthia C.T. Sprenger Kathryn S. Epilepsia B. Gayani K. Perera Mamatha Damodarasamy Shihua Sun Soojin Kim Hannah H. Hogan Matthew A. Hulverson Ryan Choi Grant R. Whitman Lynn K. Barrett Samantha A. Michaels Linda H. Xu Vicky L. Sun Samuel L.M. Arnold Haley J. Pang Matthew M. Nguyen Anna-Lena B.G. Vigil Varun Kamat Lucas B. Sullivan Ian R. Sweet Ram Vidadala Dustin J. Maly Wesley C. Van Voorhis Stephen R. Plymate

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Key Points

BKIDC-1553 and 1553-N-Me alter intracellular ATP levels across prostate cancer lines, reflecting targeted disruption of cellular energy metabolism.
Assessment of intracellular ATP occurred across LNCaP, PC3, and DU145 cell cultures to determine glycolytic response to compound exposure.
Glycolysis inhibition in these cellular lines highlights metabolic vulnerabilities in advanced prostate cancer; cell model, further preclinical validation is required.

Implication

In vitro analysis demonstrates effects of BKIDC-1553 and 1553-N-Me on intracellular ATP in prostate cancer cells, suggesting metabolic control.

Abstract

Figure S8 shows effects of BKIDC-1553 and 1553-N-Me on intracellular ATP levels in LNCaP, PC3, and DU145 cells.

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Cite This Study

Uo et al. (2024) studied this question.

synapsesocial.com/papers/68e614b1b6db6435875a74e2 https://doi.org/10.1158/1535-7163.26190722

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S13 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer2024
2Figure S4 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer2024
3Figure S12 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer2024
4Table S4 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer2024
5Table S4 from A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer2024