Lichen planopilaris (LPP) is a primary cicatricial alopecia (PCA) characterized by lymphocytic infundibulo-isthmic inflammation, resulting in the destruction of follicular bulge stem cells.1 Frontal fibrosing alopecia (FFA) and fibrosing alopecia in a pattern distribution (FAPD) are clinical variants of LPP.2 Scalp pruritus is a commonly reported symptom of LPP, potentially mediated by substance P (SP) and calcitonin gene-related peptide (CGRP) released from the dense sensory innervation of the inflamed bulge region.
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Chen et al. (2024) studied this question.
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