ZAG is secreted by TNBC cells and linked to poor prognosis. A, MDA-MB-468-secreted ZAG is highly modified (lanes 4, 5). These high molecular weight species were not observed in the secretome of ZAG depleted cells (lane 6), DMEM-only media control (lane 2), or in whole cell MDA-MB-468 lysates (lanes 8, 9). Histone 3 used as lysate loading control and also found in secretome, likely due to sparse cell death. B, TNBC outcome of combined Metabric and TCGA data sets stratified by ZAG expression. C, Table of multivariable Cox proportional hazards model shows ZAG expression is independent risk factor for poor survival in TNBC after adjusted for menopause status and therapy.
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Verma et al. (2024) studied this question.
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