An Observational Study to Assess Fasting Lipid Profile Parameters among Drug Sensitive Pulmonary Tuberculosis Patient with Type2 Diabetes Mellitus

Background and Objectives: Mycobacterium tuberculosis, can remain in the human body for decades by evading elimination by the host's immune system. Type 2 diabetes mellitus (DM) increases risk for development of tuberculosis by weakening the immune. Now, there is growing evidence towards tuberculosis linked with dyslipidaemia. We aim to compare the fasting lipid profile parameter in drug sensitive pulmonary tuberculosis patients with and without diabetes. Methods: An observational, cross -sectional and comparative study was conducted at the Department of Pulmonary Medicine, SRN Hospital, MLN Medical College, Prayagraj, from October 2022 and December 2023. Patients of pulmonary tuberculosis were split into two groups: diabetic and non -diabetic-and lipid profile was assessed. Results: The results were found to be statistically significant when comparing DM and non -DM thresholds, which showed that the fraction of DM patients of S. TC (p = 0.00) and S. TG (p = 0.00) was statistically greater as compared to NON -DM group. Conclusion: Our study suggest that low lipid levels are associated with high incidence of tuberculosis and severity of disease. And low level of highdensity lipid in diabetic patient are associated with extensive radiological lesion and severity of disease.