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July 3, 2024RNAOpen Access

Structure and sequence at an RNA template 5' end influence insertion of transgenes by an R2 retrotransposon protein

Sarah M. Palm Connor A. Horton Xiaozhu Zhang Kathleen Collins

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Abstract

R2 non-long terminal repeat retrotransposons insert site-specifically into ribosomal RNA genes (rDNA) in a broad range of multicellular eukaryotes. R2-encoded proteins can be leveraged to mediate transgene insertion at 28S rDNA loci in cultured human cells. This strategy,

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Palm et al. (2024) studied this question.

synapsesocial.com/papers/68e617f5b6db6435875aa1bc https://doi.org/10.1261/rna.080031.124

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