Antiarrhythmic Properties of Beta Blockers: Focus on Nebivolol

classification system.Beta-blockers constitute class 2 agents in the VW classification. [2]Nebivolol is a cardio-selective betablocker with additional endothelium-dependent vasodilating activity that stimulates nitric oxide (NO) synthesis, resulting in NO-mediated vasodilation.Considering its positive effects on cardiac pathologies, nebivolol can be involved in both direct and indirect treatment of rhythm disorders. [3] this article, the role of autonomic nerve activity in arrhythmias, the molecular mechanisms of action, and the pharmacological properties of Beta-Adrenergic Blockers, as AbstractBeta-blockers are commonly used medications for cardiovascular diseases.Beta-blockers are effective antiarrhythmic agents, and they are class 2 agents in the Vaughan-Williams classification.In this review, we first attempt to mention the physiology of beta-adrenergic activation in the myocardium and the role of excessive beta-adrenergic activation in arrythmiagenesis.Then, we will summarize the pharmacological properties of beta blockers and their use in specific arrhythmias.Special emphasis will be given to nebivolol, a new generation cardioselective beta-blocker with vasodilator activity, given the limited data regarding its use in arrhythmias.