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July 3, 2024International Forum of Allergy & Rhinology

The role of revision sinus surgery in the initiation of dupilumab therapy: A real‐world study of molecular and cellular features

Abigail Gaffar Abdul Rahman Alenezi Kathleen Kelly Heather Kulaga Hsin‐Tzu Keng Amy Smith Andrew P. Lane

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Abstract

Key points A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab. Revision sinus surgery immediately prior to dupilumab reduces long‐term interleukin (IL)‐4/IL‐13 tissue mRNA. Pre‐dupilumab revision surgery is associated with reduced tissue eosinophils and GATA‐3+ cells.

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Gaffar et al. (2024) studied this question.

synapsesocial.com/papers/68e61810b6db6435875ab255 https://doi.org/10.1002/alr.23401

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Early Postoperative Dupilumab After Revision Endoscopic Sinus Surgery for CRSwNP: A Real-World Single-Centre StudyCohort Study · 2026
2Revision endoscopic sinus surgery is rarely needed in dupilumab-treated chronic rhinosinusitis with nasal polyps.Original Research · 2026
3Revision endoscopic sinus surgery is rarely needed in dupilumab-treated chronic rhinosinusitis with nasal polypsOriginal Research · 2026
4Real-Life Study of Patient Preference for Dupilumab or Revision Surgery for Recurrent Chronic Rhinosinusitis with Nasal Polyps2024 · 2 citations
5The benefit of dupilumab as a postoperative short‐term adjuvant therapy for chronic rhinosinusitis with nasal polyps: A preliminary study2024 · 8 citations

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Dupilumab in Chronic Rhinosinusitis With Nasal Polyps Patients: Impact on Tissue Eosinophilic Inflammation and Eosinophil Subphenotypes2026
Prospective Real‐World Outcomes of Endoscopic Sinus Surgery and Dupilumab in Severe Chronic Rhinosinusitis With Nasal Polyps2026
Sinonasal Histopathological Changes After 12 Months of Dupilumab Treatment in Patients with Chronic Rhinosinusitis with Nasal Polyps2026

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