Abstract Psychiatric disorders exhibit diverse presentations, giving rise to a plethora of therapeutic approaches, wherein the trajectory and treatment response can serve as predictive indicators of recuperation. Catatonia, an autonomous syndrome, can manifest across various mental and organic contexts, boasting a worldwide prevalence impact of 9.2%. Even rarer is the convergence of catatonia with nihilistic delusions – a fusion exemplified by Cotard's Syndrome – a rarity observed among patients. Thus, drawing from the portrayal of a unique case involving an inaugural psychotic episode characterized by treatment resistance, the author emphasizes the importance of successive adjustments in antipsychotic therapy, fostering a more efficient approach to treating patients grappling with refractory psychotic conditions.
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Sousa et al. (2024) studied this question.
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