July 2, 2024mBioOpen Access

Pneumocystis murina promotes inflammasome formation and NETosis during Pneumocystis pneumonia

View Full Paper

Ask AI

Bookmark

Authors

SSSteven G. SaysonVeterans Health Administration AAAlan AshbaughVeterans Health Administration APAleksey PorolloCincinnati Children's Hospital Medical Center

Discussion

Member takes

Overview

Preclinical study reveals NLRP3 inflammasome activation and NETosis in murine Pneumocystis pneumonia, highlighting neutrophils as drivers of lung damage.

Key Points

Pneumocystis murina infection triggers pulmonary NLRP3 inflammasome assembly and induces NETosis, which reduces fungal viability but drives severe lung inflammation.
Mortality reaches 30% to 60% in non-HIV patients with Pneumocystis jirovecii pneumonia, and lung damage is amplified by neutrophil extracellular traps and inflammation.
RNAseq studies on a murine surrogate model identified neutrophil activation during fungal infection—mouse model; further preclinical work needed before clinical testing.

Cite This Study

Sayson et al. (2024) studied this question.

synapsesocial.com/papers/68e61a58b6db6435875aca86 https://doi.org/10.1128/mbio.01409-24

View Full Paper

Ask AI

Bookmark

July 2, 2024mBioOpen Access

Pneumocystis murina promotes inflammasome formation and NETosis during Pneumocystis pneumonia

View Full Paper

Ask AI

Bookmark

Authors

SSSteven G. SaysonVeterans Health Administration AAAlan AshbaughVeterans Health Administration APAleksey PorolloCincinnati Children's Hospital Medical Center

Discussion

Member takes

Overview

Preclinical study reveals NLRP3 inflammasome activation and NETosis in murine Pneumocystis pneumonia, highlighting neutrophils as drivers of lung damage.

Key Points

Pneumocystis murina infection triggers pulmonary NLRP3 inflammasome assembly and induces NETosis, which reduces fungal viability but drives severe lung inflammation.
Mortality reaches 30% to 60% in non-HIV patients with Pneumocystis jirovecii pneumonia, and lung damage is amplified by neutrophil extracellular traps and inflammation.
RNAseq studies on a murine surrogate model identified neutrophil activation during fungal infection—mouse model; further preclinical work needed before clinical testing.

Cite This Study

Sayson et al. (2024) studied this question.

synapsesocial.com/papers/68e61a58b6db6435875aca86 https://doi.org/10.1128/mbio.01409-24

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark