Supplementary Figure 6 from Ultrasensitive Response Explains the Benefit of Combination Chemotherapy Despite Drug Antagonism

Supplemental Figure 6. Experimental population dose responses on log-kill scale. A) Many chemotherapies exhibit exponential dose responses in hematologic cancers (left), which appear linear when plotted on a logarithmic scale (right). The first 90% cytotoxic effect is shown in green (reaching 1 log-kill); the next 90% cytotoxic effect is shown in blue (reaching 2 log-kills); the next 90% cytotoxic effect is shown in red (reaching 3 log-kills). B) Log-kills produced by CHOP and its components at concentrations from 0 to 100% Csustained. n=8 for SU-DHL-1, KHYG-1, and Ki-JK; n=4 for SMZ-1, MOT-N1, and DL-40.