July 2, 2024

Supplementary Figure S1 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3

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Target genes repressed by the EWSR1::FLI1 fusion oncoprotein demonstrate a markedly broader range of expression across EWS primary tumors than in cultured lines.
Comparative profiling of repressed gene targets contrasts cellular line models with primary tumor tissue to map focal adhesion protein alterations across cohorts.
Variable target gene repression highlights heterogeneity in tumor environments, implying cell models alone may underestimate in vivo regulation by ETS1 and TENSIN3.

Implication

Comparative analysis reveals broader EWSR1::FLI1 target expression in primary tumors, suggesting tumor environment influences transcriptional repression.

Abstract

EWSR1::FLI1 repressed gene targets defined using EWS cell lines exhibit a broader range of expression in EWS primary tumors.

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Cite This Study

Ebegboni et al. (2024) studied this question.

synapsesocial.com/papers/68e61b6eb6db6435875adaad https://doi.org/10.1158/1541-7786.26145071

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Implication

Comparative analysis reveals broader EWSR1::FLI1 target expression in primary tumors, suggesting tumor environment influences transcriptional repression.

Abstract

EWSR1::FLI1 repressed gene targets defined using EWS cell lines exhibit a broader range of expression in EWS primary tumors.

Supplementary Figure S1 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3

Key Points

Implication

Abstract

Discussion

Cite This Study

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