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Objective To explore the effects of Polygonatum King ilium and Earthworm Formula (RPEWM) on the activity of calcium-regulating enzymes and free calcium ion (Ca2+) concentration in SH-SY5Y cells with Aβ damage in vitro. Methods SH-SY5Y cells were induced to differentiate with retinoic acid, then damaged by Aβ to mimic Alzheimer's disease (AD) injury. RPEWM extract was added during the AD injury to protect the cells, and its effects on cell proliferation, apoptosis, and the activity of cellular Ca2+-ATPase､Ca2+-Mg2+- ATPase ,as well as free calcium ion concentration were observed. Results RPEWM extract significantly protected cells from AD injury, resisted apoptosis, and promoted cell proliferation; it increased the activity of intracellular Ca2+-ATPase､Ca2+-Mg2+- ATPase, reduced Ca2+ concentration, and showed a dose-dependent relationship. Conclusion RPEWM has a good protective effect on differentiated SH-SY5Y cells with Aβ25-35damage and has a certain therapeutic effect on AD.
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Wang et al. (2024) studied this question.
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