Some Novel Synthesis 2-Aroyl-1-acetylhydrazine Derivatives: An Assessment of Their Biological Activity as Therapeutic Agents

Abstract Our study provides valuable insights into the anti-cancer activity of novel acetyl hydrazine derivatives as TOP2B inhibitors in breast cancer cells. Molecular docking studies were performed to evaluate the putative bonding mode of the synthesized compounds (3a, 4, 5a,b, and 6a,b). The obtained compounds were characterized using ¹H-NMR and ¹³C-NMR. Most of the compounds exhibited significant inhibitory activity against breast cancer cell lines. Among them, compound (6b) demonstrated a remarkable anti-cancer effect by inducing G2/M phase cell cycle arrest and apoptosis.