July 1, 2024Nature GeneticsOpen Access

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis

View Full Paper

Ask AI

Bookmark

Arrested alveolar regeneration characterizes fibrotic niches in human idiopathic pulmonary fibrosis, diverging sharply from active tissue repair in mouse lung injury.
Spatially resolved transcriptome maps of human IPF (n = 4) and bleomycin-induced mouse fibrosis (n = 6) identify transforming growth factor beta as a key driver.
Supports alveolar regeneration as a therapeutic target in idiopathic pulmonary fibrosis, though acute mouse model divergence limits direct clinical translation.

Discussion

No takes yet. Share an insight, caveat, or question.

Spatial transcriptomic mapping reveals arrested alveolar regeneration in human pulmonary fibrosis, suggesting regenerative therapeutic strategies.

Franzén et al. (2024) studied this question.

View Full Paper

Ask AI

Bookmark

Spatial transcriptomic mapping reveals arrested alveolar regeneration in human pulmonary fibrosis, suggesting regenerative therapeutic strategies.