β-Cyclodextrin–NHC–Au(I)-Catalyzed Enantioconvergent 1,5-Enyne Cycloisomerizations

Enantioconvergent transformations from racemic mixtures are attractive since they allow to generate optically active products with full conversion despite the possibly adverse kinetic resolution process.When dealing with gold(I)-catalyzed cycloisomerizations, chirality transfer from the precursor is another possible diverting pathway, which renders enantioconvergence challenging.Not surprisingly, enantioconvergent Au(I)-catalyzed processes have remained extremely rare.Herein, we show that cavity-driven catalysis using β-Cyclodextrin-NHC-Au(I) complexes bring opportunities to conduct highly enantioconvergent cycloisomerizations of 1,5-enynes, -enynols and -enynyl esters.