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September 20, 2025Advanced Synthesis & CatalysisOpen Access

Gold(I)‐Catalyzed Enantioselective Cycloisomerization of 1,6‐Oxygenated Enynes: An Entry to Hedonic Derivatives

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Authors

ACAnne ClissonVMVéronique Michelet

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Overview

This report demonstrates enantioselective cycloisomerization in enynes, indicating significant advances in stereoselectivity and yields.

Key Points

  • The method achieves high enantiomeric excesses exceeding 99% in yields for 35 derivatives.
  • It utilizes a chiral cationic Au(I) catalyst system to enhance selectivity and efficiency.
  • Results highlight the versatility of chiral bicyclic ethers as intermediates for novel hedonic derivatives.
  • The investigation of odor profiles illustrates how molecular chirality influences enantiomeric perception.

Cite This Study

Clisson et al. (2025) studied this question.

synapsesocial.com/papers/68d469c131b076d99fa66577https://doi.org/10.1002/adsc.70106
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