Research demonstrates efficient synthesis of optically pure hydrindanes, suggesting versatile chemical applications.
We herein disclose a palladium-catalyzed asymmetric desymmetric cycloisomerization of alkynyl-tethered cyclohexadienes, providing optically pure hydrindanes with one tertiary and one quaternary stereocenter. This reaction features a broad substrate scope, high atom economy, and good to excellent enantioselectivities. In addition, the diene and enone motifs embedded in the products offer synthetic handles for further structural diversification.
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Lu et al. (2026) studied this question.
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