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Abstract Glioblastoma is a highly aggressive and complex pathology that has garnered significant interest among researchers and clinicians due to its high mortality rates. This research article provides a systematic analysis of key aspects related to glioblastoma, offering comprehensive insights into its underlying complexities. The text explores the epidemiological patterns, etiological factors, and genetic and molecular foundations underlying the development of GBM. It also examines the interplay between the immune system and the tumor, identifying specific immune markers with potential diagnostic value. The article describes the complex processes involved in tumor growth, including its interaction with surrounding tissues, the development of the tumor microenvironment, and the role of stem cells. It also provides an analysis of current treatment options and the challenges they face, particularly in relation to tumor resistance. The article concludes with a thorough examination of the changing landscape of diagnostic and therapeutic approaches. It highlights notable recent research findings and provides insight into potential advancements that could shape the future of medical interventions for glioblastoma.
Świątek et al. (Mon,) studied this question.