Design and synthesis of novel thiazolidinone hybrid as α-amylase inhibitor, glucose uptake and antioxidant activity

A design and synthesis of novel series of substituted thiazolidinone has been synthesised from 2-amino-thiazole and pyrazole-2-aldehyde using DCC under mild condition. These compounds were first examined for α-amylase inhibition, glucose uptake activity and antioxidant activities. The α-amylase inhibition profile was found to be competitive for compound 3b. Including, compounds 3h exhibited significant glucose update activity with IC50 values of 10.21 μM. Additionally, the free-radical scavenging activity of 3a-n was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay.