P-151 the Risk Prediction of Comorbid Pathology Development of Locomotive Drivers With Arterial Hypertension

Introduction Arterial hypertension and gastrointestinal tract diseases are common diseases and often observed in the same patients. It is expedient to develop a methodology for predicting of a comorbid pathology developing for workers in order to maintain working longevity. Methods Employees (n=127, men) of locomotive crews ofrailways (experience > 10 years) are examined. Laboratory studies: a general blood test, serum concentrations of traditional biochemical parameters, the concentration of individual proteins. Results The obtained data let to develop a mathematical formula for the developing risk of arterial hypertension in patients with erosive and ulcerative lesions of the gastroduodenal system. Discussion In patients with gastrointestinal diseases, an increase in endothelin-1> 0.8 mmol/ml in combination with an increase in platelets> 169×109/l, leukocytes> 7.8×109/l, glucose> 4.7 mmol/l, cholesterol> 3.8 mmol/l is associated with the development risk of comorbidity.The multiple regression equation describing the formation of a comorbid:Y = –1,523 + 0,703•X1 – 0,001•X2 + + 0,041•X3 + 0,134•X4 + 0,142•X5, where Y -risk of the comorbidity(“0” - no, “1” - yes), X1 - endothelin-1, X2 - blood platelets, X3 - leukocytes, X4 - glucose, X5 - cholesterol. Conclusion Locomotive drivers have an increased risk of a comorbid pathology, which is accompanied by a change in a number of laboratory parameters that can be used to predict the risk of developing comorbid pathology.