Genexpert MTB/RIF Contribution to the Diagnosis of Pulmonary Tuberculosis in People Living with HIV at the Siguiri Prefectural Hospital (Republic of Guinea)

Introduction: Tuberculosis (TB) is an infectious disease transmitted from person to person and caused by the bacillus Koch (BK).It is a major public health problem throughout the world, despite the numerous tuberculosis control strategies (TCS).Objective: To evaluate the value of Genexpert MTB/RIF in the diagnosis of pulmonary tuberculosis in PLHIV at Siguiri prefectural hospital, with a view to improving patient care.Method: This is a prospective, descriptive, cross-sectional study lasting six months, from 15 February to 15 August 2023.Results: Biological diagnosis of 200 patients revealed 85 Genexpert-positive patients, i.e. a prevalence of 42.5%, compared with 79 fluorescence microscopy-positive patients, i.e. 39.5%.The variation in viral load in the 85 patients tested positive for HIV-TB coinfection was significant in HIV-TB co-infected patients with a mean of (59277copies/ml).Immunosuppression was advanced overall, with the majority of patients in our study having an LTCD4+ level of less than 200 cells/µl.The mean LTCD4+ level was 124.52 cells/ µl, with extremes ranging from 5 to 349 cells/µl.Patients with a mean LTCD4+ level ≥ 200 cells/µl accounted for 72% of cases.Married patients were the most represented at 62%, the majority being blue-collar workers (42%), followed by housewives (19%).The 31-40 age group was the most affected, with a prevalence of 31%.The Siguiri Koura 1 and 2 neighbourhoods were the most affected by HIV-MTB co-infection, with 26% and 21% respectively. Conclusion:The present study proves that the Genexpert MTB/RIF method is the best method for diagnosing pulmonary tuberculosis compared with Microscopy (Fluorescence and Ordinary) and plays a major role in predicting multi-drug resistance, particularly to Rifampicin, in Mycobacterium tuberculosis.Its systematic use in conjunction with.