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July 1, 2024Asian Journal of Internal MedicineOpen Access

An unusual presentation of dermatomyositis: dermatomyositis sine dermatitis presenting with rapidly progressive myositis

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Authors

CMChirath MadurapperumaTPThanushiyan PoobalasingamSCS. Constantine

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Overview

Case report demonstrates recovery after combination immunotherapy in a 55-year-old woman with dermatomyositis sine dermatitis, highlighting the need for prompt care despite absent rash.

Key Points

  • Rapid progressive muscle weakness resolved following aggressive multimodal therapy with rituximab and methotrexate, restoring proximal and respiratory motor function.
  • In a 55-year-old woman, diagnostic electromyogram and muscle biopsy confirmed dermatomyositis sine dermatitis despite the absence of typical dermatologic manifestations.
  • Findings highlight that positive anti-nxp-2 antibody may signal severe inflammatory myositis, underscoring the necessity of early intervention even when classic rash is absent.

Cite This Study

Madurapperuma et al. (2024) studied this question.

synapsesocial.com/papers/68e62074b6db6435875b2192https://doi.org/10.4038/ajim.v3i2.170
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