What question did this study set out to answer?

This case examines the progression of originally diagnosed amyopathic dermatomyositis to severe systemic involvement, highlighting diagnostic challenges.

June 14, 2026CureusOpen Access

Dermatomyositis With Necrotizing Vasculitis, Pulmonary Arterial Hypertension, and Extensive Calcinosis Following Delayed Diagnosis

View Full Paper

Ask AI

Bookmark

Authors

ALAmine Laabichi WAW. Ammouri NMNaima Mouatassim

Discussion

Member takes

Overview

Case report of a woman with delayed diagnosis of dermatomyositis, leading to severe systemic manifestations and treatments.

Key Points

This case examines the progression of originally diagnosed amyopathic dermatomyositis to severe systemic involvement, highlighting diagnostic challenges.
Reported case of a 45-year-old woman with delayed diagnosis after four years with initial amyopathic dermatomyositis.
Extended myositis serology identified anti-Mi-2 and anti-SRP antibodies; muscle biopsy assessed disease severity.
Interventions included intravenous cyclophosphamide, pulmonary vasodilator therapy, colchicine, and corticosteroids.
Muscle biopsy revealed significant findings of perifascicular atrophy, necrotizing vasculitis, and granulomatous inflammation.
Right heart catheterization confirmed the presence of pre-capillary pulmonary arterial hypertension.
Treatment led to clinical and functional improvement in the patient.

Cite This Study

Laabichi et al. (2026) studied this question.

synapsesocial.com/papers/6a2e456cb1cc60ccdea8a932 https://doi.org/10.7759/cureus.110687

View Full Paper

Ask AI

Bookmark

June 14, 2026CureusOpen Access

Dermatomyositis With Necrotizing Vasculitis, Pulmonary Arterial Hypertension, and Extensive Calcinosis Following Delayed Diagnosis

View Full Paper

Ask AI

Bookmark

Authors

ALAmine Laabichi WAW. Ammouri NMNaima Mouatassim

Discussion

Member takes

Overview

Case report of a woman with delayed diagnosis of dermatomyositis, leading to severe systemic manifestations and treatments.

Key Points

This case examines the progression of originally diagnosed amyopathic dermatomyositis to severe systemic involvement, highlighting diagnostic challenges.
Reported case of a 45-year-old woman with delayed diagnosis after four years with initial amyopathic dermatomyositis.
Extended myositis serology identified anti-Mi-2 and anti-SRP antibodies; muscle biopsy assessed disease severity.
Interventions included intravenous cyclophosphamide, pulmonary vasodilator therapy, colchicine, and corticosteroids.
Muscle biopsy revealed significant findings of perifascicular atrophy, necrotizing vasculitis, and granulomatous inflammation.
Right heart catheterization confirmed the presence of pre-capillary pulmonary arterial hypertension.
Treatment led to clinical and functional improvement in the patient.

Cite This Study

Laabichi et al. (2026) studied this question.

synapsesocial.com/papers/6a2e456cb1cc60ccdea8a932 https://doi.org/10.7759/cureus.110687

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark