Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies

M.K.-H. Scha ̈fer; Camille Amalric; Roberto Arban; Luc Baron; Sami Ben Hamida; Petra Breh-Schlanser; Yunhai Cui; Emmanuel Darcq; Christian Eickmeier; Vincent Faye; Christel Franchet; Mélanie Frauli; Célia Halter; Marjorie Heyer; Christoph Hoenke; S. Hoerer; Oliver Hucke; Christophe Joseph; Brigitte L. Kieffer; Louison Lebrun; N. Lotz; Stanislas Mayer; Azar Omrani; Mandy Recolet; Laurent Schaeffer; Stéphan Schann; Annette Schlecker; Edith Steinberg; Mélanie Viloria; Klaus Würstle; Kyle Young; Alexander Zinser; Florian Montel; Julian Klepp

doi:10.1021/acs.jmedchem.4c00665

Abstract

Decreased activity and expression of the G-protein coupled receptor GPR88 is linked to many behavior-linked neurological disorders. Published preclinical GPR88 allosteric agonists all have

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̈fer et al. (2024) studied this question.

synapsesocial.com/papers/68e62088b6db6435875b2f61 https://doi.org/10.1021/acs.jmedchem.4c00665

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Abstract

Decreased activity and expression of the G-protein coupled receptor GPR88 is linked to many behavior-linked neurological disorders. Published preclinical GPR88 allosteric agonists all have

Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies

Abstract

Discussion

Cite This Study

Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for In Vivo Mouse Studies

Abstract

Discussion

Cite This Study

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