P-505 Occupational Exposure to Pesticides and Testicular Germ Cell Tumor in the Testis Pro Study

Introduction With an incidence of 2769 cases in 2018 in France, testicular cancer is a “rare” cancer, however an increase in the incidence of TGT has been observed in recent decades. Recently, the link with pesticide exposure has begun to be suspected, but the data are currently discordant. The aim of the TESTISPRO study is to estimate the effects of individual occupational exposure to pesticides on the risk of developing a testicular tumor in adulthood, in young men of childbearing age. Methods The TESTISPRO study is a multicenter case-control study based in 20 French university hospitals between January 2015 and April 2018. 1124 participants (454 cases; 670 controls) were included and interviewed in the study. They were given a standardized questionnaire assessing their occupational exposure to pesticides. The results were analyzed by evaluators to define a level of pesticide exposure per individual according to a predefined standardized scale. Results Exposure to low levels of pesticides is associated with an OR of 1.15 [IC95% 0.64-2.04], while exposure to high levels of pesticides is significantly associated with a crude OR of 1.65 [IC95% 1.03-2.66]. The trend test is significant (p=0.02). Discussion These results suggest a positive association between occupational exposure to pesticides and the risk of TGT, also supported by a significant dose-effect. Conclusion This is the first study to show an association between testicular germ cell tumors and occupational exposure to pesticides. These results need to be confirmed by additional studies, particularly to elucidate potential pathophysiological mechanisms.