Pd29-05 Pesticides and Prostate Cancer Incidence and Mortality: An Environmental Wide Association Study

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I (PD29)1 May 2024PD29-05 PESTICIDES AND PROSTATE CANCER INCIDENCE AND MORTALITY: AN ENVIRONMENTAL WIDE ASSOCIATION STUDY Simon John Christoph Soerensen, David S. Lim, Maria E. Montez-Rath, Glenn M. Chertow, Benjamin I. Chung, David H. Rehkopf, and John T. Leppert Simon John Christoph SoerensenSimon John Christoph Soerensen , David S. LimDavid S. Lim , Maria E. Montez-RathMaria E. Montez-Rath , Glenn M. ChertowGlenn M. Chertow , Benjamin I. ChungBenjamin I. Chung , David H. RehkopfDavid H. Rehkopf , and John T. LeppertJohn T. Leppert View All Author Informationhttps://doi.org/10.1097/01.JU.0001008736.23117.7f.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer is the most common cancer among men. Risk factors other than age, race, and family history remain unclear. A large-scale investigation of exposure to agricultural pesticides could identify pesticides that warrant further scrutiny as potential risk factors for prostate cancer incidence and mortality. The objective was to describe county-level associations between 295 pesticides and incidence and mortality of prostate cancer in the contiguous U.S. METHODS: In this large-scale environment-wide association study (EWAS), we conducted linear regression analyses to explore the relationships between 295 pesticides and prostate cancer incidence and mortality across counties in the contiguous U.S., while accounting for multiple testing and adjusting for relevant confounders. The discovery cohort examined pesticide use in 1997-2001 and evaluated prostate cancer incidence and mortality outcomes in 2011-2015. The replication cohort examined pesticide use in 2002-2006 and outcomes in 2016-2020. Final candidate pesticides were determined if they met significance criteria in both cohorts, with associations in the same direction. Prior to running each regression analysis, we log-transformed and z-score normalized each independent variable. RESULTS: We identified statistically significant associations between 22 pesticides and prostate cancer incidence in both discovery and replication cohorts (Figure 1). Four of these pesticides were clinically significant and consistently associated with prostate cancer mortality. In the replication cohort, the incidence effect sizes (95% CI) of these four pesticides were: Trifluralin, 6.56 (5.04 to 8.07); cloransulam-Methyl, 6.18 (4.06 to 8.31); diflufenzopyr, 3.20 (1.09 to 5.31); and thiamethoxam, 2.82 (1.14 to 4.5). CONCLUSIONS: This EWAS approach found 22 pesticides consistently associated with incidence of prostate cancer at the county level. Four of these pesticides were also associated with prostate cancer mortality. These findings suggest that pesticide exposure may contribute to variations in prostate cancer incidence and mortality and highlight the need for further research into the potential health impacts of these specific classes of pesticides. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e620 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Simon John Christoph Soerensen More articles by this author David S. Lim More articles by this author Maria E. Montez-Rath More articles by this author Glenn M. Chertow More articles by this author Benjamin I. Chung More articles by this author David H. Rehkopf More articles by this author John T. Leppert More articles by this author Expand All Advertisement PDF downloadLoading ...